Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp193 | Thyroid - Basic | ECE2016

Interconnection between cathepsin protein levels and thyroid hormone transporters in human thyroid epithelial cells

Kizilirmak Cise , Qatato Maria , Weber Jonas , Rehders Maren , Fuhrer Dagmar , Brix Klaudia

BackgroundThyroid hormone transporting proteins Mct8 and Mct10 have been detected at the plasma membrane of thyroid epithelial cells, whereas Lat2 was found predominantly at vesicular membranes. In this study we look into the effects of inhibiting thyroid hormone transporters on their subcellular localisation to better understand their fate and trafficking pathways in thyrocytes. Thus, a pharmacological intervention study with specific inhibitors of thyr...